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Full NameDr Kevin Mitchell
- genetics, genomics and molecular biology
- neuroscience and mental health
- Paediatrics
- Neurology
The Mitchell lab is interested in the genetics of neural development and of neurodevelopmental disorders. We study these processes using experimental genetic approaches in mice and genetic analyses in humans. We have identified and characterised numerous genes in the mouse that are involved in controlling neuronal cell migration, axonal guidance and synaptic specificity during brain development. Defects in these processes can lead to neurological disturbances, such as seizures, as well as behavioural phenotypes of relevance to psychiatric disorders. We are currently using statistical methods to dissect the genetic architecture of schizophrenia, analysing large-scale genetically characterised samples.
Future work will involve genome-sequencing studies of patients with paediatric epilepsies, cortical malformations or unexplained developmental delay. We aim to identify new disorders of cortical development and model them in mice to elucidate pathogenic mechanisms.
The Genetics of Neurodevelopmental Disorders (Edited by Kevin J. Mitchell)
www.wiley.com/buy/9781118524886