Supervisor View 2
October 3, 2016Supervisor View Full Details 2nd
October 12, 2016Prof Michael Rowan
Department:Pharmacology & Therapeutics
Organisation:Trinity College Dublin
Webpage:http://www.medicine.tcd.ie/research/researchers/rowan.php
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- neuroscience and mental health
- Medicine
- Surgery
- Dementia
- Geriatric Medicine
- Neurology
- Neurophysiology
- Neuropsychiatry
- Pharmacology
- Psychiatry
A major focus of our research is how misfolded proteins affect synaptic plasticity, in particular the Alzheimer's disease-related amyloid ? protein (A?), tau and alpha synuclein.
The underlying core proposition of the present proposal is that synaptic plasticity disrupting soluble assemblies of disease-related proteins, in particular amyloid ? (A?) and tau, underlie key aspects of early Alzheimer?s disease (AD). The overall objective of the programme of research is to profile the synaptic plasticity disrupting assemblies in human samples of induced pluripotent stem cell (iPSC)-derived neurons and cerebrospinal fluid (CSF) and to determine their relationship to similar assemblies in well-characterized brain samples from people with AD. We study these phenomena in acutely anaesthetized and awake freely behaving rats in a transgenic model using standard electrophysiological methods and novel optogenetic techniques.
For our publications and citations see: https://scholar.google.com/scholar?hl=en&q=Rowan%2C+m.j.&btnG=&as_sdt=1%2C5&as_sdtp=